Subchondral Bone Analysis

Articular Cartilage Area, Length, and Thickness

Images courtesy of Prof. Oran Kennedy, Royal College of Surgeons in Ireland. Click image to enlarge.

Mineralized Cartilage Area, Length, and Thickness

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Subchondral Bone Plate Area, Length, and Thickness

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Chondrocyte Distribution and Number

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Trabecular Bone Structure

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Recent Citations of BIOQUANT in Osteoarthritis Research

Featured
Osteoarthritis, ACLT, IL-1β, TMMG, Macrophage, Osteoclast
A glucuronated flavone TMMG spatially targets chondrocytes to alleviate cartilage degeneration through negative regulation of IL-1β
Osteoarthritis, ACLT, IL-1β, TMMG, Macrophage, Osteoclast
Osteoarthritis, ACLT, IL-1β, TMMG, Macrophage, Osteoclast
arthritis, hfd, myeloid discoidin domain receptor 2
Ablation of myeloid discoidin domain receptor 2 exacerbates arthritis and high fat diet induced inflammation
arthritis, hfd, myeloid discoidin domain receptor 2
arthritis, hfd, myeloid discoidin domain receptor 2
osteoarthritis, ageing, miRNAs
Exosomal transfer of osteoclast-derived miRNAs to chondrocytes contributes to osteoarthritis progression
osteoarthritis, ageing, miRNAs
osteoarthritis, ageing, miRNAs
osteoarthritis, knee, sPLA2
Phospholipase A2 inhibitor-loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression
osteoarthritis, knee, sPLA2
osteoarthritis, knee, sPLA2
rheumatoid arthritis, GILZ, mouse, inflammation, bone loss
Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss
rheumatoid arthritis, GILZ, mouse, inflammation, bone loss

TNF-α plays a key role in the development of rheumatoid arthritis (RA) and inflammatory bone loss. Unfortunately, treatment of RA with anti-inflammatory glucocorticoids (GCs) also causes bone loss resulting in osteoporosis. Our previous studies showed that overexpression of glucocorticoid-induced leucine zipper (GILZ), a mediator of GC’s anti-inflammatory effect, can enhance osteogenic differentiation in vitro and bone acquisition in vivo.

rheumatoid arthritis, GILZ, mouse, inflammation, bone loss