Kristin Reveal August 4, 2016 model animal Association Between Progranulin and Gaucher Disease Kristin Reveal August 4, 2016 model animal Gaucher disease (GD) is a genetic disease caused by mutations in the GBA1 gene which result in reduced enzymatic activity of β-glucocerebrosidase (GCase). This study identified the progranulin (PGRN) gene (GRN) as another gene associated with GD.