AUTHORS
Shuo Wang, Zuodong Zhao, Qingtao Zhang, Chang Liu
ABSTRACT
Objective
To evaluate the effectiveness of a mini-implant composed of unsintered hydroxyapatite, poly (L-lactic acid) and poly(lactic-co-glycolic acid) (u-HA/PLLA/PLGA) composites as an anchorage device under consistent orthodontic force (OF) loading in vivo.
Methods
An mandible model in beagle dogs was introduced. 144 mini-implants were implanted in both sides of the mandibles. The mini-implants in the experimental group (left side) were loaded at the magnitude of 200 g to simulate the OF. At 2, 4 and 6 months after implantation, tissue specimens were taken from the implanted sites and biomechanical, histological and histomorphometrical analysis were performed.
Results
Mini-implants in the group with the highest PLLA ratio showed a 27% non-fracture rate after 4 months and 20.83% after 6 months in beagle dogs, and the non-fractured mini-implants could maintain the tensile force of 200 g, while mini-implants in the other two groups were all fractured. Histomorphological analysis showed that there was no significant relationship between Bone Volume over Total Volume (BV/TV) and the implantation time among the most of the groups. The level of Bone-Implant Contact ratio (BIC) in Medium and Low ratio group were decreased gradually from 2 to 6 months.
Conclusions
This study showed the biodegradable mini-implant could work as an alternative to the titanium alloy mini-implant by adjusting the proportion of its ingredients.
Clinical relevance
Degradable mini-implants for orthodontic anchorage lie in their potential to revolutionize orthodontic treatments by offering a biodegradable alternative that minimizes the need for secondary surgeries for removal, thereby enhancing patient comfort and reducing overall treatment time.