A HISTOMORPHOMETRIC EVALUATION OF THE EFFECTS OF PLATELETRICH FIBRIN AND RIFAMYCIN IN COMBINATION WITH AN ALLOGRAFT ON BONE AUGMENTATION WITH SIMULTANEOUS IMPLANT PLACEMENT IN RABBIT TIBIA

Authors

İlker ÖZEÇ, Sancar ŞİMŞEK, Emre BENLİDAYI, Mehmet KÜRKÇÜ

Abstract

Objective:
To evaluate the potential of platelet-rich fibrin (PRF) and rifamycin to enhanceguided bone augmentation with simultaneous high-profile dental implant placement in a rabbit tibia model.

Materials and Methods:
Dental implants protruding 2 mm were covered with dome-shaped stiff occlusive titanium barriers filled with demineralized freeze-dried bone allograft (DFDBA)+saline (7 rabbits), DFDBA + rifamycin (8 rabbits), or DFDB +PRF (8 rabbits). After 4 weeks, the animals were sacrificed, and undecalcified histomorphometric examination with toluidine blue staining was performed.

Results:
The bone-to-implant contact (BIC) was 58.43 ± 1.92% in the saline group, 68.3 ±20.37% in the rifamycin group, and 80.70±2.55% in the PRF group, and the percentage of new bone formation was 36.90 ± 0.94%, 45.26±0.60%, and 51.82±0.82%, respectively.

Conclusions:
Both PRF and rifamycin have potential to enhance GBA, and using DFDBA + PRF or DFDBA+rifamycin beneath a stiff occlusive titanium barrier next to a high-profile implant may enhance both BIC and new bone formation.